Although resource-efficient processes like inkjet printing have a large potential to foster the development of smart and functional textiles, one bottleneck still is the development of functional inks. To make inkjet printing and UV curing given production techniques for smart and functional specialty products, e.g. photochromic textiles, deepened knowledge about the development, rheological behavior and jetting behavior of functional ink is needed. This paper focuses on the formulation and performance of UV-responsive and UV-curable inkjet inks, which are based on photochromic dyes and their application to produce UV-responsive textiles. Two commercial photochromic dyes—Reversacol Ruby Red (RR) and Sea Green (SG), which represent dyes of the naphthopyran and spirooxazine class, respectively, have been used to develop the inks. The photochromic inks are characterized according to their physical–chemical and rheological properties in respect to temperature. The influence of temperature on the drop formation of the inks in an industrial print head is analyzed using a high-speed camera, which reveals important information regarding challenges in ink jettability. It was found that the dye structure and type used in the ink can influence the jetting behavior of photochromic UV-curable ink. More pronounced temperature sensitivity of dyes can increase the temperature-related effects of drop formation as was observed for SG ink. The printability of the RR and SG inks is framed and underpinned by theoretical calculations of the Z number. Discrepancies are observed and discussed between existing theory of ink jettability and visual evaluation of the photochromic ink.