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  • 1. Behboudi, A
    et al.
    Roshani, L
    Kost-Alimova, M
    Sjöstrand, E
    Montelius-Alatalo, K
    Röhme, D
    Klinga-Levan, K
    Ståhl, Fredrik
    Göteborg University.
    Detailed Chromosomal and Radiation Hybrid Mapping in the Proximal Part of the Rat Chromosome 10 and gene order Comparison with Mouse and Human2002Ingår i: Mammalian Genome, ISSN 0938-8990, E-ISSN 1432-1777, Vol. 13, nr 6, s. 302-309Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The rat provides valuable and sometimes unique models of human complex diseases. To fully exploit the rat models in biomedical research, it is important to have access to detailed knowledge of the rat genome organization as well as its relation to the human genome. Rat Chromosome 10 (RNO10) harbors several important cancer-related genes. Deletions in the proximal part of RNO10 were repeatedly found in a rat model for endometrial cancer. To identify functional and positional candidate genes in the affected region, we used radiation hybrid (RH) mapping and single- and dual-color fluorescence in situ hybridization (FISH) techniques to construct a detailed chromosomal map of the proximal part of RNO10. The regional localization of 14 genes, most of them cancer-related (Grin2a, Gspt1, Crebbp, Gfer, Tsc2, Tpsb1, Il9r, Il4, Irf1, Csf2, Sparc, Tp53, Thra1, Gh1), and of five microsatellite markers (D10Mit10, D10Rat42, D10Rat50, D10Rat72, and D10Rat165) was determined on RNO10. For a fifteenth gene, Ppm1b, which had previously been assigned to RNO10, the map position was corrected to RNO6q12-q13.

  • 2. Gómez-Fabre, PM
    et al.
    Helou, K
    Ståhl, Fredrik
    Predictions based on the rat-mouse comparative map provide mapping information on over 6,000 new rat genes2002Ingår i: Mammalian Genome, ISSN 0938-8990, E-ISSN 1432-1777, Vol. 13, nr 4, s. 189-193Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    For identification of ECS (``evolutionarily conserved segments'') between rat and mouse, 893 rat–mouse orthologous gene-pairs were brought together with zoo-FISH analysis. In total, 59 autosomal ECS and 4 X-chromosomal ones were detected. Combining FISH and zoo-FISH data, the segments were anchored on the rat chromosomes, providing an improved comparative map between the two species. Since chromosomal evolution is a slow process, it is reasonable to assume that the genome organization, including gene order, is essentially conserved within the ECS. In this way we assigned tentative subchromosomal map positions to 303 rat genes, for which no regional mapping information was available. Furthermore, the concept of prediction mapping was extended to unmapped rat homologs of genes, which in the mouse are situated inside or in the vicinity of an ECS. For a total of 6669 genes, we predicted a single rat chromosomal position, whereas for another 448 genes we could predict that they were located in one of two possible positions. Thus, our study has increased the number of genes for which there is positional mapping information in the rat almost fivefold.

  • 3. Helou, K
    et al.
    Waltentinsson, A
    Levan, G
    Ståhl, Fredrik
    Between rat and mouse zoo-FISH reveals 49 chromosomal segments that have been conserved in evolution2001Ingår i: Mammalian Genome, ISSN 0938-8990, E-ISSN 1432-1777, Vol. 10, nr 12, s. 765-771Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Mouse single chromosome paints were applied to rat prophase/prometaphase chromosomes to detect homologous chromosome regions. The analysis revealed 49 rat chromosomal regions ranging in size from whole chromosomes down to small bands near the limit of detection with this method, which was estimated to be 2-3 Mb. When all the painted regions were taken into account, the whole rat genome was covered with mouse-homologous regions, with the exception of small segments near the centromeres and the short arms of Chromosomes (Chrs) 3, 11, 12, and 13. These regions were shown to contain high levels of rat-specific repetitive DNA. The number of conserved segments between rat and mouse detected by our high-resolution zoo-FISH method was significantly higher than that reported in previous studies.

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