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  • 1. Behboudi, A
    et al.
    Roshani, L
    Lundin, L
    Ståhl, Fredrik
    Högskolan i Borås, Institutionen för Vårdvetenskap.
    Klinga-Levan, K
    Levan, G
    Functional significance of absence: The chromosomal segment harboring the Tp53 gene is missing in the T55 rat radiation hybrid mapping panel2002Ingår i: Genomics, ISSN 0888-7543, E-ISSN 1089-8646, Vol. 79, nr 6, s. 844-848Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The T55 rat radiation hybrid (RH) mapping panel has been reported to retain the entire rat genome at retention frequencies between 22% and 37%. However, we found that a small segment of rat chromosome 10 harboring at least four different genes, including Tp53, was completely absent from the panel (retention frequency = 0%). Two other markers located in the vicinity exhibited much reduced retention (2–6%). RH clones are generated by transferring highly fragmented DNA into a recipient cell. There might be a strong selection against the transfer and retention of chromosome segments harboring an intact Tp53, as the action of this gene might prevent proliferation and establishment of the RH clone. Our finding further suggests that unexpected low retention or absence of chromosome segments in an RH panel may represent indications that the segments harbor genes with important functions in cell proliferation control.

  • 2. Nilsson, S
    et al.
    Helou, K
    Walentinsson, A
    Szpirer, C
    Nerman, O
    Ståhl, Fredrik
    Högskolan i Borås, Institutionen för Vårdvetenskap.
    Rat-mouse and rat-human comparative maps based on gene homology and high resolution zoo-FISH2001Ingår i: Genomics, ISSN 0888-7543, E-ISSN 1089-8646, Vol. 74, nr 3, s. 287-298Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The laboratory rat, Rattus norvegicus, and the laboratory mouse, Mus musculus, are key animal models in biomedical research. A deeper understanding of the genetic interrelationsships between Homo sapiens and these two rodent species is desirable for extending the usefulness of the animal models. We present comprehensive rat–human and rat–mouse comparative maps, based on 1090 gene homology assignments available for rat genes. Radiation hybrid, FISH, and zoo-FISH mapping data have been integrated to produce comparative maps that are estimated to comprise 83–100% of the conserved regions between rat and mouse and 66–82% of the conserved regions between rat and human. The rat–mouse zoo-FISH analysis, supported by data for individual genes, revealed nine previously undetected conserved regions compared to earlier reports. Since there is almost complete genome coverage in the rat–mouse comparative map, we conclude that it is feasible to make accurate predictions of gene positions in the rat based on gene locations in the mouse.

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