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Lack of very strong association between pre-treatment fibrinogen and PAI-1 with long-term mortality after coronary bypass surgery.
[external].
2007 (English)In: Cardiology, ISSN 0008-6312, E-ISSN 1421-9751, Vol. 108, no 2, 82-89 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To explore the association between the coagulation protein fibrinogen and the fibrinolytic biomarker plasminogen activator inhibitor-1 (PAI-1) and the long-term mortality after coronary artery bypass grafting (CABG). PATIENTS AND METHODS: In 729 patients undergoing CABG at Sahlgrenska University Hospital, a blood sample for fibrinogen and PAI-1 was collected prior to the procedure. Patients were followed for 10 years. RESULTS: Among patients with high levels of fibrinogen (>3.6 g/l; median), the 10-year mortality was 32.3 vs. 20.7% among patients with fibrinogen levels below the median (p = 0.0005). However, patients with higher levels of fibrinogen were older and had an adverse risk factor pattern. When adjusting for these differences, pre-operative fibrinogen levels did not clearly appear as an independent predictor of long-term mortality. The 10-year mortality was similar in patients with high (25.3%) and low (26.5%) levels of PAI-1. CONCLUSION: Our results do not suggest that fibrinogen and PAI-1, when evaluated prior to the operative procedure, are strongly associated with increased mortality in the long-term after CABG, when other co-morbidity factors are simultaneously considered.

Place, publisher, year, edition, pages
S. Karger AG , 2007. Vol. 108, no 2, 82-89 p.
Keyword [en]
fibrinogen, coronary artery surgery, prognosis, plasminogen activator inhibitor
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hb:diva-8063DOI: 10.1159/000095935Local ID: 2320/9848OAI: oai:DiVA.org:hb-8063DiVA: diva2:888946
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-10-14Bibliographically approved

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