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Factors associated with development of stroke long-term after myocardial infarction: experiences from the LoWASA trial
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2005 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 257, no 2, 201-207 p.Article in journal (Refereed)
Abstract [en]

OBJECTIVE: To describe factors associated with the development of stroke during long-term follow-up after acute myocardial infarction (AMI) in the LoWASA trial. PATIENTS: Patients who had been hospitalized for AMI were randomized within 42 days to receive either warfarin 1.25 mg plus aspirin 75 mg daily or aspirin 75 mg alone. DESIGN: The study was performed according to the probe design, that is open treatment and blinded end-point evaluation. SETTING: The study was performed in 31 hospitals in Sweden. The mean follow-up time was 5.0 years with a range of 1.7-6.7 years. RESULTS: In all, 3300 patients were randomized in the trial, of which 194 (5.9%) developed stroke (4.2% nonhaemorrhagic, 0.5% haemorrhagic and 1.3% uncertain. The following factors appeared as independent predictors for an increased risk of stroke: age, hazard ratio and 95% confidence interval (1.07; 1.05-1.08), a history of diabetes mellitus (2.4; 1.8-3.4), a history of stroke (2.3; 1.5-3.5), a history of hypertension (2.0; 1.5-2.7) and a history of smoking (1.5;1.1-2.0). Most of these factors were also predictors of a nonhaemorrhagic stroke whereas no predictor of haemorrhagic stroke was found. CONCLUSION: Risk indicators for stroke long-term after AMI were increasing age, a history of either diabetes mellitus, stroke, hypertension or smoking.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Ltd. , 2005. Vol. 257, no 2, 201-207 p.
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Medical and Health Sciences
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URN: urn:nbn:se:hb:diva-8004DOI: 10.1111/j.1365-2796.2004.01433.xLocal ID: 2320/8933OAI: oai:DiVA.org:hb-8004DiVA: diva2:888887
Available from: 2015-12-22 Created: 2015-12-22

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CiteExportLink to record
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Citation style
  • apa
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More styles
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