Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Increased serum levels of the S100 protein are associated with hypoxic brain damage after cardiac arrest
[external]. (Prehospital akutsjukvård)
1998 (English)In: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 29, no 2, 473-477 p.Article in journal (Refereed)
Abstract [en]

BACKGROUND AND PURPOSE: Patients resuscitated from cardiac arrest have a high early mortality rate. Prognostic evaluation based on clinical observations is uncertain and would benefit from the use of biochemical markers of hypoxic brain damage. The astroglial protein S-100 is an established biochemical marker of central nervous system injury. The purpose of the present study was to validate the use of serum determinations of S-100 with regard to outcome after cardiac arrest. METHODS: Levels of serum S-100 were measured with a radioimmunoassay in 41 patients the first 3 days after out-of-hospital cardiac arrest. The main outcome variable was fatal outcome within 14 days. RESULTS: S-100 levels were increased after cardiac arrest compared with controls with the highest levels observed the first day. S-100 levels day 1 and 2 correlated to the degree of coma as well as to the time of anoxia. Seventeen patients died within 14 days after the cardiac arrest. The deceased patients had increased S-100 levels on days 1 through 3 compared with survivors. All patients (100%) with an S-100 level of > or =0.2 on day 2 after the cardiac arrest died within 14 days, and 89% of the patients with levels below this limit value survived (positive and negative predictive values). The corresponding predictive values on day 1 were 71% and 85%, respectively. CONCLUSIONS: The present study shows that hypoxic brain damage after cardiac arrest can be estimated by measurement of serum S-100 concentrations. The method can be used in early prognostic evaluation of short-term outcome after cardiac arrest.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins , 1998. Vol. 29, no 2, 473-477 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hb:diva-7846Local ID: 2320/8814OAI: oai:DiVA.org:hb-7846DiVA: diva2:888728
Available from: 2015-12-22 Created: 2015-12-22

Open Access in DiVA

No full text

Other links

http://stroke.ahajournals.org/content/29/2/473.full.pdf+html

Search in DiVA

By author/editor
Herlitz, Johan
In the same journal
Stroke
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Total: 50 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf