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Feasibility of insulin-glucose infusion in diabetic patients with acute myocardial infarction. A report from the multicenter trial: DIGAMI
[external].
1994 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 17, no 9, 1007-1014 p.Article in journal (Refereed)
Abstract [en]

OBJECTIVE--To investigate the effect of insulin-glucose infusion on metabolic control and hypoglycemic episodes and its feasibility and safety in patients with diabetes and myocardial infarction (MI) compared with conventional treatment. RESEARCH DESIGN AND METHODS--Of 327 patients with suspected acute MI 158 were randomized to insulin-glucose infusion for at least 24 h and 169 received conventional therapy. We determined the 24-h blood glucose profile in the infusion group, the degree of metabolic control, hypoglycemic events, and in-hospital complications within the two study groups. RESULTS--Blood glucose fell from 14.6 +/- 2.9 to 9.2 +/- 2.9 mM during the first 24 h in patients receiving insulin-glucose and from 15.8 +/- 4.3 to 12.0 +/- 4.4 mM in control patients (P < 0.01). Serum potassium decreased 0.21 +/- 0.56 mM in the infusion group (P < 0.001) and 0.11 +/- 0.59 mM in the control group (P < 0.05). The difference between the groups was not significant. Twenty-eight of the 158 patients developed an episode of hypoglycemia (blood glucose < 3.0 mM) during the insulin-glucose infusion. There were no significant differences in the number of episodes of ventricular tachyarrhythmias or in ischemic events between patients with and without hypoglycemia. CONCLUSIONS--The protocol outlined in this study gives more rapid and better metabolic control than does conventional treatment. This treatment seems to be a feasible alternative for clinical attempts. Before it can be recommended for general use, the impact on mortality needs to be evaluated.

Place, publisher, year, edition, pages
American Diabetes Association , 1994. Vol. 17, no 9, 1007-1014 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hb:diva-7750DOI: 10.2337/diacare.17.9.1007Local ID: 2320/8566OAI: oai:DiVA.org:hb-7750DiVA: diva2:888631
Available from: 2015-12-22 Created: 2015-12-22

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