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Effect on early intravenous rt-PA on infarct size estimated from serum enzyme activity: results from the TEAHAT Study
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1991 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 734, no suppl 1, 11-18 p.Article in journal (Refereed) Published
Abstract [en]

In 319 patients who participated in a double-blind trial to evaluate the effect of early rt-PA administration compared to placebo in suspected acute myocardial infarction, infarct size was assessed from analyses of serum activity of lactate dehydrogenase isoenzyme 1 (LD 1). Treatment was always started less than 3 h after the onset of symptoms, with one-third of the patients' treatment being initiated outside the hospital. The maximum activity of LD 1 was reduced by 32%, from 13.3 mu kat l-1 in placebo to 9.0 mu kat l-1 in rt-PA treated patients (P = 0.001). A reduction in LD-1 activity after rt-PA treatment was restricted to patients with ST-elevation in the initial electrocardiogram, and was more pronounced in patients with previous ischaemic heart disease, above median age, and in those with a shorter delay in initiation of treatment. We conclude that very early intravenous treatment with rt-PA limits indirect signs of infarct size. The effect appears to be restricted to patients with ST-segment elevation in their initial electrocardiogram.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Ltd. , 1991. Vol. 734, no suppl 1, 11-18 p.
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Medical and Health Sciences
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URN: urn:nbn:se:hb:diva-7679Local ID: 2320/8551OAI: oai:DiVA.org:hb-7679DiVA: diva2:888560
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-10-16Bibliographically approved

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