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Early use of metoprolol and serum potassium in suspected acute myocardial infarction
[external].
1989 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 22, no 2, p. 169-175Article in journal (Refereed) Published
Abstract [en]

In 1350 patients with suspected acute myocardial infarction, serum potassium was analysed in the emergency ward. The effect of metoprolol was compared with placebo in a double-blind randomized trial. Metoprolol increased serum potassium from 4.11 ± 0.02 mmol/l to 4.27 ± 0.02 mmol/l (P<0.001) during the 1st day after hospital admission, whereas serum potassium levels remained fairly constant in patients given placebo during the same time (4.11 ± 0.02 to 4.14 ± 0.02 mmol/l; P>0.2). Similar results were obtained when analysing patients with a confirmed myocardial infarction separately. The effects appeared homogeneously distributed in subgroups related to sex, clinical history, infarct site, infarct size and delay time from onset of symptoms to start of treatment. We conclude that early treatment with the beta-1-selective blocker metoprolol in patients with suspected acute myocardial infarction increases serum potassium.

Place, publisher, year, edition, pages
Elsevier Ireland Ltd , 1989. Vol. 22, no 2, p. 169-175
Keywords [en]
meroprolol, myocardial infraction, potassioum
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hb:diva-7655DOI: 10.1016/0167-5273(89)90065-XLocal ID: 2320/8445OAI: oai:DiVA.org:hb-7655DiVA, id: diva2:888536
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-12-01Bibliographically approved

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Herlitz, Johan

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