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Mortality and morbidity during a five-year follow-up of diabetics with myocardial infarction
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1988 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 224, no 1, p. 31-38Article in journal (Refereed) Published
Abstract [en]

In 787 patients with acute myocardial infarction originally participating in the Göteborg Metoprolol Trial, mortality and morbidity during 5 years' follow-up were assessed and related to whether patients had diabetes mellitus. Diabetes occurred in 78 patients (10%). Patients with diabetes had a different risk factor pattern, including higher age, higher occurrence of angina pectoris and hypertension, whereas smoking habits did not differ. In the early phase (hospitalization), patients with diabetes had a higher mortality (12% versus 8%), required more treatment for heart failure and stayed longer in hospital. Other morbidity aspects, such as severity of pain, occurrence of severe supraventricular and ventricular arrhythmias, high-degree AV-block and infarct size did not differ. During 5 years' follow-up mortality rate in patients with diabetes mellitus was 55% as compared with 30% among patients with no diabetes (P<0.001). Reinfarction rate during 5 years was 42% in daibetics versus 25% in non-diabetics (P<0.001). In a multivariate analysis, taking into account the differences in risk factor pattern, diabetes turned out to be an independent determinant for long-term mortality and reinfarction (P<0.001). We conclude that patients with diabetes mellitus, developing acute myocardial infarction, is a group with particularly high risk of death and reinfarction. Interventions aiming at its reduction have priority.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Ltd. , 1988. Vol. 224, no 1, p. 31-38
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Medical and Health Sciences
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URN: urn:nbn:se:hb:diva-7651DOI: 10.1111/j.0954-6820.1988.tb16735.xLocal ID: 2320/8439OAI: oai:DiVA.org:hb-7651DiVA, id: diva2:888532
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-09-26Bibliographically approved

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