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Relationship between enzymatically estimated infarct size and short- and long-term survival after acute myocardial infarction
[external].
1984 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 216, no 3, 261-267 p.Article in journal (Refereed)
Abstract [en]

In 585 patients with acute myocardial infarction (AMI) and no previous MI the maximal activity of serum heat-stable lactate dehydrogenase (LD) (EC 1.1.1.27) activity was related to 1-year and 2-year mortality rates. All patients participated in a double-blind trial with metoprolol during the first three months after an AMI. Thereafter both groups were treated in a similar way. A strong relationship was found between LD maximum activity and the in-hospital prognosis (p<0.001), the 1-year survival rate (p<0.001) and the 2-year survival rate (p<0.001). When the patients who were alive after primary hospitalization were analyzed as a separate group, the relationship between LD maximum activity and 1-year and 2-year survival rates remained (p<0.001). In a subsample of 171 patients the maximal activity of creatine kinase (CK) (EC 2.7.3.2) and CK subunit B did not correlate either with in-hospital, 1-year or 2-year survival rates. We conclude that, when a sufficiently large number of patients are investigated, there is a strong relationship between serum enzyme maximum activity and short- and long-term survival.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Ltd. , 1984. Vol. 216, no 3, 261-267 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hb:diva-7595Local ID: 2320/8530OAI: oai:DiVA.org:hb-7595DiVA: diva2:888475
Available from: 2015-12-22 Created: 2015-12-22

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