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Time lapse from estimated onset of acute myocardial infarction to peak serum enzyme activity
[external].
1984 (English)In: Clinical Cardiology, ISSN 0160-9289, E-ISSN 1932-8737, Vol. 7, no 8, 433-440 p.Article in journal (Refereed) Published
Abstract [en]

In 581 patients with acute myocardial infarction (MI), the time lapse from estimated onset of infarction to estimated peak serum (S) enzyme activity was evaluated. Heat-stable lactate dehydrogenase (LD; E.C. 1.1.1.27) was analyzed every 12 h for 48-108 h after arrival in hospital (n = 581) and creatine kinase (CK; E.C. 2.7.3.2.; n = 224), and creatine kinase subunit B (CK-B; n = 211) were analyzed every 6 h for 48 h. Peak S-LD was observed between 14 and 110 h after estimated onset of MI (mean 46.6 +/- 0.6 h), peak S-CK was observed between 8 and 58 h (mean 25.0 +/- 0.6 h), and peak S-CK-B was also observed between 8 and 58 h (mean 22.8 +/- 0.7 h) after onset. In 86% of patients, peak LD was reached within 60 h after onset of MI, in 78%, peak CK was reached within 30 h, and in 82%, peak CK-B was observed within 30 h after onset of MI. A weak correlation was found between duration of pain and time lapse to S peak enzyme activity (r = 0.25 -0.27; p less than 0.001), while there was no correlation between S peak activity and time lapse from onset of MI to S peak activity. It is concluded, that although in the majority of patients with MI, peak serum-enzyme activity is reached within a predictable amount of time after estimated onset of MI there is wide variation, difficult to establish from the clinical course, among individual patients.

Place, publisher, year, edition, pages
John Wiley & Sons, Inc , 1984. Vol. 7, no 8, 433-440 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hb:diva-7592DOI: 10.1002/clc.4960070803Local ID: 2320/8454OAI: oai:DiVA.org:hb-7592DiVA: diva2:888472
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-09-25Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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