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Hemodynamic and clinical findings after combined therapy with metoprolol and nifedipine in acute myocardial infarction
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1984 (English)In: Clinical Cardiology, ISSN 0160-9289, E-ISSN 1932-8737, Vol. 7, no 8, p. 425-432Article in journal (Refereed) Published
Abstract [en]

In a double-blind trial, 30 patients with suspected acute myocardial infarction with onset of symptoms within the previous 24 h were randomized to treatment with 10 mg nifedipine/placebo orally 4 times a day during hospitalization. All patients were given 15 mg metoprolol intravenously 20 min after the initial administration of nifedipine/placebo, and thereafter, 50 mg 4 times a day. The combined therapy resulted only in moderate changes in systolic blood pressure and heart rate compared with metoprolol alone. Three of the 15 patients in the nifedipine group versus 2 of the 15 in the placebo group were withdrawn because of hypotension and/or bradycardia. None was withdrawn because of congestive heart failure or A-V block. It is concluded that the combination of nifedipine and metoprolol seems to be a relatively well-tolerated combination in acute myocardial infarction.

Place, publisher, year, edition, pages
John Wiley & Sons, Inc. , 1984. Vol. 7, no 8, p. 425-432
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Medical and Health Sciences
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URN: urn:nbn:se:hb:diva-7591Local ID: 2320/8528OAI: oai:DiVA.org:hb-7591DiVA, id: diva2:888471
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-09-13Bibliographically approved

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Herlitz, Johan

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