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Göteborg Metoprolol Trial: enzyme-estimated infarct size
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1984 (English)In: American Journal of Cardiology, ISSN 0002-9149, E-ISSN 1879-1913, Vol. 53, no 13, p. 15-21Article in journal (Refereed) Published
Abstract [en]

In 1,375 patients serum activity of heat-stable lactate dehydrogenase (LD; E.C.1.1.1.27.) was analyzed every twelfth hour for 48 to 108 hours. The mean maximum LD activity was 11.1 +/- 0.4 mu kat X 1(-1) in the metoprolol group vs 12.4 +/- 0.5 mu kat X 1(-1) in the placebo group (p = 0.054). In patients in whom treatment was started 12 hours or less after the onset of pain, a 17% reduction in LD activity was observed (p = 0.009) and similar results were found in patients randomized 8 hours or less. Groups in which the effect after metoprolol treatment was more pronounced were those with an initially higher heart rate and also those with anterior myocardial infarction.

Place, publisher, year, edition, pages
Elsevier , 1984. Vol. 53, no 13, p. 15-21
National Category
Medical and Health Sciences
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URN: urn:nbn:se:hb:diva-7584Local ID: 2320/8497OAI: oai:DiVA.org:hb-7584DiVA, id: diva2:888464
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-09-13Bibliographically approved

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