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Göteborg Metoprolol Trial: design, patient characteristics and conduct
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1984 (English)In: American Journal of Cardiology, ISSN 0002-9149, E-ISSN 1879-1913, Vol. 53, no 13, 3D-8D p.Article in journal (Refereed)
Abstract [en]

The Göteborg Metoprolol Trial was a double-blind, placebo-controlled, stratified trial aimed at evaluating the effect of the beta 1-selective blocker, metoprolol, in suspected acute myocardial infarction and during 2 years of follow-up. The primary end-point was 3-month mortality (blind treatment period). Secondary end-points were 2-year mortality, indirect signs of infarct size, chest pain, arrhythmias and tolerability. The entry criteria were fulfilled in 2,802 patients, 1,395 of whom were included in the trial. Treatment started as soon as possible after arrival in hospital with intravenous administration followed by oral treatment for 3 months. All patients were randomized 48 hours or less after estimated onset of infarction and 69% were randomized at 12 hours or less. The blind treatment had to be withdrawn in 19% of all randomized patients before the end of the 3-month follow-up.

Place, publisher, year, edition, pages
Excerpta Medica, Inc. , 1984. Vol. 53, no 13, 3D-8D p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hb:diva-7582Local ID: 2320/8475OAI: oai:DiVA.org:hb-7582DiVA: diva2:888462
Available from: 2015-12-22 Created: 2015-12-22

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