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Relationship between infarct size and incidence of severe ventricular arrhythmias in a double-blind trial with metoprolol in acute myocardial infarction
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1984 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 6, no 1, p. 47-60Article in journal (Refereed) Published
Abstract [en]

In 585 patients having an acute myocardial infarction for the first time the relationship was investigated between estimated infarct size and the incidence of ventricular fibrillation and treated ventricular tachycardia during hospitalization. The size of the infarct was estimated from analyses of heat stable lactate dehydrogenase (LD) (EC 1.1.1.27.) in serum collected every 12 hr for 48–108 hr. All patients participated in a double-blind comparison of the β1-selective blocker metoprolol with placebo in suspected acute myocardial infarction. A correlation was observed between the enzymatically estimated infarct size and the incidence of ventricular fibrillation and treated ventricular tachycardia in patients on placebo (P < 0.001), while this could not be demonstrated in patients on the beta-blocker (P > 0.2). In placebo treated patients there was a correlation between the maximum heat stable LD activity and early ventricular fibrillation (P = 0.034), late ventricular fibrillation (P < 0.001), primary ventricular fibrillation (P = 0.002) as well as secondary ventricular fibrillation (P = 0.034). It is concluded that there seems to be a relatively strong correlation between the final size of the infarction and the occurrence of severe ventricular arrhythmias. Treatment with beta-blockade appeared to disturb this correlation.

Place, publisher, year, edition, pages
Elsevier Ireland Ltd , 1984. Vol. 6, no 1, p. 47-60
Keywords [en]
drug treatment
Keywords [sv]
beta-blockade
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hb:diva-7581DOI: 10.1016/0167-5273(84)90245-6Local ID: 2320/8473OAI: oai:DiVA.org:hb-7581DiVA, id: diva2:888461
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-09-27Bibliographically approved

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Herlitz, Johan

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