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Intraneural electrical stimulation of cutaneous nociceptive fibres in humans: effects of different pulse patterns on magnitude of pain
University of Borås, Faculty of Caring Science, Work Life and Social Welfare.
1992 (English)In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 146, no 1, p. 41-48Article in journal (Refereed) Published
Abstract [en]

A study was performed to elucidate how different impulse frequencies and impulse patterns in cutaneous nociceptive fibres influence the subjective magnitude of pain. Groups of nociceptive Aδ and C fibres were co-activated by electrical intraneural stimulation at constant intensity in cutaneous fascicles of the peroneal nerve in healthy human subjects. The resulting pain sensations were rated on a modified visual analogue scale. Five-second trains were administered randomly at irregular intervals of at least 30 s. Five of the stimulus patterns had regular interpulse intervals, corresponding to frequencies of 1, 2, 4, 10 and 15 Hz, and three other patterns were constructed to mimic to some extent the initially phasic and subsequently slowly adapting discharge patterns which may be encountered in recordings from human nociceptors. The results from these experiments using stimulation frequencies within physiological discharge ranges for human nociceptors indicate that the subjective magnitude of pain increases monotonously as a function of stimulus frequency, and that patterns mimicking nociceptor discharges in response to natural stimuli give rise to greater peak magnitudes of pain than artificial regular patterns with a corresponding number of impulses.

Place, publisher, year, edition, pages
Wiley-Blackwell , 1992. Vol. 146, no 1, p. 41-48
Keywords [en]
humans, intra-neural stimulation, nociceptive fibres, pain, temporal summation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hb:diva-7517DOI: 10.1111/j.1748-1716.1992.tb09391.xLocal ID: 2320/8392OAI: oai:DiVA.org:hb-7517DiVA, id: diva2:888380
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-10-28Bibliographically approved

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Lundberg, Lars

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