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Tumorigenicity of SEWA murine tumor cells correlates with degree of c-myc amplification
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1988 (English)In: Oncogene, ISSN 0950-9232, E-ISSN 1476-5594, Vol. 3, no 4, p. 437-441Article in journal (Refereed) Published
Abstract [en]

Previous studies have shown that cells of the SEWA mouse tumor contain amplified copies of the proto-oncogene c-myc in the aberrant chromosomal structures of double minutes (DMs), homogeneously staining regions (HSRs) and C-bandless chromosomes (CMs). DMs, and to a lesser degree CMs, tend to disappear from the cells grown in vitro and again reappear after transfer back in vivo, as if DNA amplification confers a growth advantage upon the tumor cells. We have now isolated five in vitro clones that exhibit different degrees of c-myc amplification. When we inoculated cells of the different clones into compatible hosts, we found that there was a positive correlation between degree of c-myc amplification, level of c-myc RNA, and tumorigenicity. Our results lend further support to the idea that gene amplification contributes to the higher malignant phenotype, and to progression of tumors.

Place, publisher, year, edition, pages
Nature Publishing Group , 1988. Vol. 3, no 4, p. 437-441
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Medical and Health Sciences
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URN: urn:nbn:se:hb:diva-7462Local ID: 2320/7560OAI: oai:DiVA.org:hb-7462DiVA, id: diva2:888325
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-10-06Bibliographically approved

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Ståhl, Fredrik

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