The looming spectre of decline of the man-made fibre industry in US, Europe and Japan has been exacerbated by several problems like intense global cost pressure, fibre and raw material shortages, oil price volatility challenges etc. All of these have contributed to sluggish growth and higher bankruptcies. Resiliency in such a context has become a prerequisite for leading long term business prosperity fuelled by diverse technological innovations. In this paper, the authors have investigated an inexorable phenomenon of quantifying and correlating innovation and business resiliency from annual financial data for DuPont, as a case, over a span of five decades. The findings are manifold. The financial impact of blockbuster products based on disruptive technologies takes over a decade to yield results while contributions from sustaining innovations are swift. Both types of innovations are necessary. Incremental innovations delay product maturity with concomitant investments in costly and risky blockbuster product developments. From DuPont’s perspective, the company showed explosive growth from 1970-90, primarily fuelled by the rapid introduction of products with long product lifecycle developed during 1950-1965. However, DuPont performance started to indicate declining resiliency even while increasing investments in innovation, from 1960-2010. This is possibly due to change in product portfolio from commodity to specialty orientation.