There is a need to better understand the organizational factors influencing innovative performance. This cross-cultural study examined organizational support factors in biotech R&D groups differing in innovative performance. The objective was to twofold; first to explore how organizing influences innovativeness in R&D, and, second to examine if R&D organizing is related to nations having a low and high innovation degree, respectively. Results supported that organizing R&D as well as national innovation performance are related. Crucial organizational issues found were how much organizations encouraged innovations, the degree of perceived autonomy and to what extent organizations could supply knowledge. Some of the implications of these results are introduced.