In the past decade, a number of scientific collaboratories have emerged, yet adoption of scientific collaboratories remains limited. Meeting expectations is one factor that influences adoption of innovations, including scientific collaboratories. This paper investigates expectations scientists have with respect to scientific collaboratories. Interviews were conducted with 17 scientists who work in a variety of settings and have a range of experience conducting and managing scientific research. Results indicate that scientists expect a collaboratory to: support their strategic plans; facilitate management of the scientific process; have a positive or neutral impact on scientific outcomes; provide advantages and disadvantages for scientific task execution; and provide personal conveniences when collaborating across distances. These results both confirm existing knowledge and raise new issues for the design and evaluation of collaboratories.