Young knowledge-intensive firms must create markets for their products when transforming new technologies into innovation. The main objective of the paper is to examine the strategies and decision logics involved when university spin-offs use inter-organizational networks to cope with the unscertainties that surround the entrepreneurial process of market creation. The paper is based on a quasi-inductive methodological approach; first an exploratory case study of a spin-off company originating from Lund University and followed by a follow-up survey to a broader sample of incubator start-ups across Sweden.