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Long-term prognostic value of mitral regurgitation in acute coronary syndromes
University of Borås, School of Health Science.
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2010 (English)In: Heart, ISSN 1355-6037, E-ISSN 1468-201X, Vol. 96, 1803-1808 p.Article in journal (Refereed)
Abstract [en]

Objectives To determine the additional prognostic value of mitral regurgitation (MR) over B-type natriuretic peptide (BNP), left ventricular ejection fraction (LVEF) and clinical characteristics in patients with acute coronary syndromes (ACS). Design Long-term follow-up in a prospective ACS cohort with Doppler-assessed MR, echocardiographically-determined LVEF and plasma BNP levels by ELISA. Setting Single-centre university hospital. Patients 725 patients with ACS. Main outcome measures Death and readmission for congestive heart failure. Results During a median follow-up of 98 months, 235 patients (32%) died. Significant MR (grade >1 of 4) was found in 90 patients (12%). In a multivariate model including MR grade >1, LVEF <0.40 and BNP >373 pg/ml (75th percentile), MR was significantly associated with long-term mortality (HR 2.28, 95% CI 1.67 to 3.12; p<0.0001). When also adjusting for conventional risk factors, MR remained significantly associated with mortality (HR 1.53, 95% CI 1.06 to 2.19; p=0.02), as well as with congestive heart failure (HR 2.08, 95% CI 1.29 to 3.35; p=0.003). Conclusions MR is common in patients with ACS, provides independent risk information and should be taken into account in the evaluation of the long-term prognosis.

Place, publisher, year, edition, pages
BMJ Group , 2010. Vol. 96, 1803-1808 p.
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
URN: urn:nbn:se:hb:diva-2992DOI: 10.1136/hrt.2010.203059Local ID: 2320/7389OAI: oai:DiVA.org:hb-2992DiVA: diva2:871087
Available from: 2015-11-13 Created: 2015-11-13

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CiteExportLink to record
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