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Does indomethacin for closure of patent ductus arteriosus affect cerebral function?
University of Borås, School of Engineering.
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2010 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 99, no 10, 1493-1497 p.Article in journal (Refereed)
Abstract [en]

Objective: To study whether indomethacin used in conventional dose for closure of patent ductus arteriosus affects cerebral function measured by Electroencephalograms (EEG) evaluated by quantitative measures. Study design: Seven premature neonates with haemodynamically significant persistent ductus arteriosus were recruited. EEG were recorded before, during and after an intravenous infusion of 0.2 mg/kg indomethacin over 10 min. The EEG was analysed by two methods with different degrees of complexity for the amount of low-activity periods (LAP, “suppressions”) as an indicator of affection of cerebral function. Results: Neither of the two methods identified any change in the amount of LAPs in the EEG as compared to before the indomethacin infusion. Conclusion: Indomethacin in conventional dose for closure of patent ductus arteriosus does not affect cerebral function as evaluated by quantitative EEG.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Ltd. , 2010. Vol. 99, no 10, 1493-1497 p.
Keyword [en]
Medicinteknik
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Biomedical Laboratory Science/Technology
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URN: urn:nbn:se:hb:diva-2846DOI: 10.1111/j.1651-2227.2010.01857.xLocal ID: 2320/6892OAI: oai:DiVA.org:hb-2846DiVA: diva2:870940
Available from: 2015-11-13 Created: 2015-11-13

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