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ECG and heart rate variability changes in preterm and near-term fetal lamb following LPS exposure
University of Borås, School of Engineering.
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2008 (English)In: Reproductive Sciences, ISSN 1933-7191, E-ISSN 1933-7205, Vol. 15, no 6, p. 572-583Article in journal (Refereed) Published
Abstract [en]

The aim of this study is to evaluate the myocardial response in the preterm and near-term fetal lamb with infection. Chronically instrumented fetal lambs were exposed to lipopolysaccharide (LPS), and the fetal electrocardiogram (FECG) ST waveform was examined using STAN. Fetal heart rate variability (FHRV) was automatically analyzed by adapting a polynomial function to the RR sequence in the FECG. Preterm fetuses exposed to >90 ng/kg LPS died within 8 hours of LPS administration, a response not seen in near-term fetuses. In both surviving and nonsurviving preterm fetuses, cardiovascular responses were characterized by decreased arterial pressure, negative T waves, and tachycardia accompanied by an increase in FHRV. Similar changes were not observed in the near-term fetuses after LPS. The study shows that preterm lambs are more sensitive to LPS in terms of myocardial/cardiovascular response than the more mature fetuses are. High FHRV and negative ST waveform seem to characterize the LPS-induced stress response in preterm fetuses.

Place, publisher, year, edition, pages
Sage Publications, Inc. , 2008. Vol. 15, no 6, p. 572-583
Keywords [en]
intrauterine infection, STAN, heartrate monitoring, Medicinteknik
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:hb:diva-2560DOI: 10.1177/1933719107314060Local ID: 2320/4593OAI: oai:DiVA.org:hb-2560DiVA, id: diva2:870654
Available from: 2015-11-13 Created: 2015-11-13 Last updated: 2017-11-24Bibliographically approved

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Rosén, Karl-Gustaf

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