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Lipid raft protecome of the human neutrophil azurophil granule.
University of Borås, School of Engineering.
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2007 (English)In: Proteomics, ISSN 1615-9853, E-ISSN 1615-9861, Vol. 7, no 2, p. 194-205Article in journal (Refereed) Published
Abstract [en]

Detergent-resistant membrane domains (DRMs) are present in the membranes of azurophil granules in human neutrophils (Feuk-Lagerstedt et al., J. Leukoc. Biol. 2002, 72, 970). Using a proteomic approach, we have now identified 106 proteins in a DRM preparation from these granule membranes. Among these proteins were the lipid raft structural proteins flotillin-1 and -2, cytoskeletal proteins such as actin, vimentin and tubulin, and membrane fusion promoting proteins like annexins and dysferlin. Our results suggest that the azurophil granule membrane, in similarity to the plasma membrane, is an elaborate structure that takes part in intracellular signaling and functions other than the mere delivery of bactericidal effector molecules to the phagosome.

Place, publisher, year, edition, pages
Wiley - VCH Verlag GmbH & Co. KGaA , 2007. Vol. 7, no 2, p. 194-205
Keywords [en]
azurophil granules, detergent resistant membrane domains, lipid rafts, nanolc-ms/ms
Keywords [sv]
Energi och material
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:hb:diva-2356DOI: 10.1002/pmic.200600482Local ID: 2320/3134OAI: oai:DiVA.org:hb-2356DiVA, id: diva2:870447
Available from: 2015-11-13 Created: 2015-11-13 Last updated: 2018-01-10Bibliographically approved

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