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Transient repolarization alterations dominate the initial phase of an acute anterior infarction-a vectorcardiography study
University of Borås, School of Health Science. (Prehospital akutsjukvård)
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2014 (English)In: Journal of Electrocardiology, ISSN 0022-0736, E-ISSN 1532-8430, Vol. 47, no 4, p. 478-485Article in journal (Refereed) Published
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Abstract [en]

OBJECTIVE: To study effects of ischemia-reperfusion on ventricular electrophysiology in humans by three-dimensional electrocardiography. METHODS: Fifty-seven patients with first-time acute anterior ST elevation myocardial infarction were monitored from admission and >24h after symptom onset with continuous vectorcardiography (VCG; modified Frank orthogonal leads). Global ventricular depolarization and repolarization (VR) measures were compared at maximum vs. minimum ST vector magnitude (STVM) (median 208; 111-303 vs. 362; 165-1359min after symptom onset). RESULTS: At maximum vs. minimum STVM the Tarea (overall VR dispersion) almost tripled (118 vs. 41μVs; p<0.0001), the T-loop bulginess was 90% greater (Tavplan 0.91 vs 0.48μV; p<0.0001), and Tpeak-end/QT was 39% larger (0.32 vs 0.23; p<0.0001). QRSarea (overall dispersion of depolarization) was 12% larger at maximum STVM, while QRS duration was 10% longer at minimum STVM. CONCLUSIONS: Ischemia-reperfusion was accompanied by profound and transient alterations of VR dispersion, while changes in depolarization were modest and delayed.

Place, publisher, year, edition, pages
Churchill Livingstone , 2014. Vol. 47, no 4, p. 478-485
Keywords [en]
Kardiologi
National Category
Cardiac and Cardiovascular Systems
Research subject
Integrated Caring Science
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URN: urn:nbn:se:hb:diva-1995DOI: 10.1016/j.jelectrocard.2014.04.017PubMedID: 24891262Local ID: 2320/14545OAI: oai:DiVA.org:hb-1995DiVA, id: diva2:870076
Available from: 2015-11-13 Created: 2015-11-13 Last updated: 2017-12-04Bibliographically approved

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Herlitz, J

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