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Changes in medication preceededing out-of hopital cardiac arrest where resuscitation was attempted
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2014 (English)In: Journal of Cardiovascular Pharmacology, ISSN 0160-2446, E-ISSN 1533-4023, Vol. 63, no 6, p. 497-503Article in journal (Refereed) Published
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Abstract [en]

OBJECTIVE: To describe recent changes in medication preceding out-of-hospital cardiac arrest (OHCA) where resuscitation was attempted. METHODS: OHCA victims were identified by the Swedish Cardiac Arrest Register and linked by means of their unique 10-digit personal identification numbers to the Prescribed Drug Register. We identified new claimed prescriptions during a 6-month period before the OHCA compared with those claimed in the period 12 to 18 months before. The 7-digit Anatomical Therapeutical Chemical codes of individual drugs were used. The study period was November 2007-January 2011. RESULTS: OHCA victims with drugs were (1) older than those who did not claim any drugs in any period (70 ± 16 years vs. 54 ± 22 years, P < 0.001), (2) more often women (34% vs. 20%, P < 0.001), and (3) had more often a presumed cardiac etiology (67% vs. 54%, P < 0.001). The OHCA victims were less likely to have ventricular tachycardia/ventricular fibrillation as the first recorded rhythm (26% vs. 33%, P < 0.001) or to survive 1 month (9% vs. 17%, P < 0.0001). New prescriptions were claimed by 5122 (71%) of 7243 OHCA victims. The most frequently claimed new drugs were paracetamol (acetaminophen) 10.3%, furosemide 7.8%, and omeprazole 7.6%. Of drugs known or supposed to cause QT prolongation, ciprofloxacin was the most frequent (3.4%) altogether; 16% had a new claimed prescription of a drug included in the "qtdrugs.org" lists. CONCLUSIONS: Most OHCA victims had new drugs prescribed within 6 months before the event but most often intended for diseases other than cardiac. No claims can be made as to the causality.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins , 2014. Vol. 63, no 6, p. 497-503
Keywords [sv]
Prehospital Akutsjkvård
National Category
Cardiac and Cardiovascular Systems
Research subject
Integrated Caring Science
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URN: urn:nbn:se:hb:diva-1987DOI: 10.1097/FJC.0000000000000073PubMedID: 24390174Local ID: 2320/14534OAI: oai:DiVA.org:hb-1987DiVA, id: diva2:870065
Available from: 2015-11-13 Created: 2015-11-13 Last updated: 2017-11-29Bibliographically approved

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Herlitz, J

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