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IGM-phosphorylcholine autoantibodies and outcome in acute coronary syndromes.
University of Borås, School of Health Science.
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2013 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 167, no 2, p. 464-469Article in journal (Refereed) Published
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Abstract [en]

BACKGROUND: Antibodies against proinflammatory phosphorylcholine (anti-PC) seem to be protective and reduce morbidity. We sought to determine whether low levels of immunoglobulin-M (IgM) autoantibodies against PC add prognostic information in acute coronary syndromes (ACS). METHODS: IgM anti-PC titers were measured in serum obtained within 24h of admission from 1185 ACS patients (median age 66 years, 30% women). We evaluated major acute cardiovascular events (MACE) and all-cause mortality short--(6 months), intermediate--(18 months) and long--(72 months) terms. RESULTS: Low anti-PC titers were associated with MACE and all-cause mortality at all follow-up times. After adjusting for clinical variables, plasma troponin-I, proBNP and CRP levels, associations remained at all times with MACE, short and intermediate terms also with all-cause mortality. With anti-PC titers below median, adjusted hazard ratios at 18months were for MACE 1.79 (95% confidence interval [CI]: 1.31 to 2.44; p=0.0002) and for all-cause mortality 2.28 (95% CI: 1.32 to 3.92; p=0.003). Anti-PC and plasma CRP were unrelated and added to risk prediction. CONCLUSIONS: Serum IgM anti-PC titers provide prognostic information above traditional risk factors in ACS. The ease of measurement and potential therapeutic perspective indicate that it may be a valuable novel biomarker in ACS.

Place, publisher, year, edition, pages
Elsevier Ireland Ltd , 2013. Vol. 167, no 2, p. 464-469
Keywords [sv]
Vårdutveckling
National Category
Cardiac and Cardiovascular Systems
Research subject
Integrated Caring Science
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URN: urn:nbn:se:hb:diva-1680DOI: 10.1016/j.ijcard.2012.01.018ISI: 000320768800037PubMedID: 22305633Local ID: 2320/13051OAI: oai:DiVA.org:hb-1680DiVA, id: diva2:869749
Available from: 2015-11-13 Created: 2015-11-13 Last updated: 2017-11-16Bibliographically approved

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CiteExportLink to record
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