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Molecular diagnostic markers in endometrial carcinoma: an overview
University of Borås, School of Health Science.
2013 (English)In: Journal of Oncopathology, ISSN 2052-5931, Vol. 1, no 2, 145-150 p.Article in journal (Refereed)
Sustainable development
The content falls within the scope of Sustainable Development
Abstract [en]

Endometrial, ovarian, and cervical cancers are three of the most common malignancies of the female reproductive organs and the most common cause of gynecological cancer deaths in the Western world. Approximately 80% or more of endometrial cancers are low-grade, estrogen-dependent, endometrioid adenocarcinoma (type I), whereas 20% are high-grade endometrial carcinomas (type II) associated with poor prognosis. Although endometrial cancer is usually diagnosed at an early stage, still almost 20% of the patients present with advanced disease. Thus, there is a need for highly sensitive markers that can distinguish between high- and low-risk endometrial carcinoma. To date, however, there are no validated molecular markers for endometrial cancer. Recent genomic and proteomic-based anaes show great promise for the discovery of new and more useful biomarkers. In this review, we will discuss the currently reported biomarkers that hold potential as diagnostic tools for endometrial cancer.

Place, publisher, year, edition, pages
Optimal Clinical Ltd. , 2013. Vol. 1, no 2, 145-150 p.
Keyword [en]
endometrial carcinoma, Medicin
National Category
Cancer and Oncology
Research subject
Integrated Caring Science
Identifiers
URN: urn:nbn:se:hb:diva-1619Local ID: 2320/12696OAI: oai:DiVA.org:hb-1619DiVA: diva2:869688
Available from: 2015-11-13 Created: 2015-11-13

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