The purpose of this paper is to analysis and present that antagonistic threats against supply chain activities are wicked problems. The research is based on a system-theoretical approach, which emphasizes a holistic view instead of the characteristics of the different parts. The research method used in this paper is deductive desk research. This research is mainly theoretical, and the findings are contributions to the development of theoretical models and understanding in order to further move the scientific understanding about antagonistic threats against supply chain activities. The main reason behind this is the relationship between threats and countermeasures that are complex and contextual depended. There are several types of crime that can be linked to the logistics function and processes. This paper does not address the problems from a legal viewpoint. This paper presented descriptions of four different antagonistic threats, namely theft, terrorism, smuggling and piracy. The nature of these four different antagonistic threats is then analyzed with regards to the wicked problem description, which leads to the conclusion that antagonistic threats are better described as wicked problems.