The present study examines two regions in the south west of Sweden. A number of factors which are of significant importance in creating resilient family businesses as well as regions are identified. The study is based on a literature investigation and on 60 interviews of leaders in business and communities. Thereby, the study contributes to the scarce literature on resilience in family businesses and the interdependence with regional culture. Resilience in this paper refers to a particular type of economic and structural crisis which has not been considered before. We highlight similarities and differences of two regions in Sweden which have distinct regional cultures. These cultures support the development of resiliency. However, owning families as facilitators for organizational resilience play the central role. Their closeness and involvement in the business allows them to act fast and take decisions quickly which makes them more resilient.