Waste to the product approach was proposed for tuning environ-threat soybean husk towards lipolytic enzyme by integrating the invasive weed optimization with biomass and product dynamics study. The invasive weed optimization constitutes based on the non-linear regression model results in a 47 % enhancement in lipolytic enzyme using the optimization parameters of 7% Sigma Final, 9% exponent; S_max of 5 with a population size of 35 and Max. generations of 99. The biomass dynamic study showcases the dynamic parameters of 0.0239 µ_max, 8.17 X_Lim^st and 0.852 R_Fin values. The product dynamic studies reveal the kinetic parameters of k^st, k^div, P_Fin, which seem to be equal to -0.0338, 0.0896 and 68.1, respectively. Overall, the present study put forth the zero-waste (soybean husk) to the product (lipolytic enzyme) approach by introducing the novel "Invasive Weed Optimization" coupled with "Biomass and product dynamics" to the bioprocessing field.