This study aims to analyse the information seeking behaviour of postgraduate students from Eduardo Mondlane University, Medicine Faculty, in order to extend the knowledge about the students’ interaction with study-related information as well as their perception in relation to the electronic resources available through UEM library, and the challenges they encounter seeking and retrieving information. To carry out the research, a qualitative and quantitative approach was used based on combination with the semi-structured interview and online survey as data collection instruments. The results showed that students start their searches with quite clearly defined information needs and varied seeking purposes, with emphasis on solving tasks of their master's and PhD classes, as well as to write and publish scientific articles. Students are aware of the existence of electronic resources available through the university, with emphases to the medical database HINARI. However, they prefer to use other sources freely available on the internet such as Google scholar andPubMed and they do not have the necessary skills to adopt precise strategies for information seeking. Issues such as unstable Internet connection, language barriers, difficulties in computing and use ofd atabases, and limitations on access to documents that require payments are some of the main challenges faced by the students during informationseeking.