Several feedstocks for anaerobic digestion (AD) have challenges that hamper the success of AD with their low accessible surface area, biomass recalcitrance, and the presence of natural inhibitors. This paper presents different types of pretreatment to address those individual challenges and how they contribute to facilitate AD. Organosolv and ionic liquid pretreatments are effective to remove lignin without a significant defect on lignin structures. To deal with accessible surface area and crystallinity, comminution, steam explosion, pretreatment using N-methyl-morpholine-N-oxide methods are suggested. Moreover, solid extraction, simple aeration, and biological treatments are capable in removing natural inhibitors. Up to date, methods like comminution, thermal process, and grinding are more preferable to be scaled-up. © 2020 Elsevier Ltd