Biorefinery perceived as impeccable encouraging perspective of generating multiple bio-products from organic solid waste through integration of various relevant techniques. With the improved attractiveness of circular bio-economy as a greatly potential approach in view of social soaring energy demands and biodiversity conservation, biorefinery contributed as sustainable strategic mechanism for emerging circular bio-economy. Present study outlined a comprehensive review of the status for organic solid waste derived from agriculture, industry and urban toward to available biorefinery approach. In addition, evaluated techno-economic assessment and proposed the current bottleneck challenges and future perspective for sustainability of circular bio-economy in China. The results demonstrated that the diversity kinds of solid waste played an essential role in implement of biorefinery in circular bio-economy. Achieving sustainable circular bio-economy requires coordinated development of economic, environment and social. There is still a great gap between actual performance with expectation of biorefinery in bio-economy, comprehensive investigations and depth exploration were critical for sustainability.