The growth of e-health system has influenced the way health organizations conduct their business. Communication between these systems is one of the most significant factors since a more efficient communication system can improve an organization performance. Nowadays the health organizations make a lot of investments to deploy a suitable information and communication technology to meet their goals. This study investigates the health information exchange within different health information systems. We first carried out a theoretical study to find out the relevant concepts by reviewing the related literature and analyzing them. As a result of our theoretical study we investigate and redesign the basic model of the “Super Clinic” as a new model for health information exchange system. Then we conducted an empirical study to validate the result from the theoretical study which helped us to narrow down our research area. We revised our proposed theoretical model by the lesson learnt from our empirical study results. Three interviews were conducted with experts and the outcomes were analyzed using comparative analysis. These interviews allowed us to outline the most important factors of successful health information exchange systems (i.e. “Super Clinic”). They also helped us to design a central hub (i.e. “health Hub”) for communication and information exchange between different information systems. This revised model of Super Clinic (with the central hub) could be going under more investigation in future works.