Polyelectrolytes are conductive polymers because of their ionic side group and PEDOT-S is one of those conductive polyelectrolytes. Previously, recombinant silk fibre has been dyed with PEDOT-S. PEDOT-S showed that it can be dyed with recombinant silk fibre over a very wide range of pH from 11 to 1.7. Previous experiments of dyeing recombinant silk fibre with PEDOT-S has shown that it is a very versatile process and can also be applied on other types of protein-based fibres, and that prompted me to dye wool and silk fibre from Bombyx Mori and make these fibres functionalized. So in this thesis dyeing of wool and silk fibres with PEDOT-S has been carried out. By this bottom-up approach of making an organic polymer electrically conductive and utilising the flexibility of organic polymer, one can integrate it in OLEDs and in smart textiles. In this thesis dyeing of silk and wool fibres with different dyeing pH has been carried out to maximise the exhaustion of dyes on to the fibres to acquire maximum conductance. Then the wool and silk fibres’ conductance and mechanical properties after dyeing were compared. Wool showed better conductance and mechanical properties as compare to silk after being dyed with PEDOT-S. These results helped to propose a model that tells about the interaction between protein-based fibres and polyelectrolytes and gives us better understanding of how these protein-based fibres show certain conductivity at different pH. Results also showed that these conductive fibres can be used further in special purposes and applications.