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On-line estimation of sugar concentration for control of fed-batch fermentation of lignocellulosic hydrolyzates by Saccharomyces cerevisiae
Department of Chemical Engineering II, Lund Institute of Technology.
Department of Chemical Engineering II, Lund Institute of Technology.ORCID iD: 0000-0003-4887-2433
Department of Chemical Engineering II, Lund Institute of Technology.
2002 (English)In: Bioprocess and biosystems engineering (Print), ISSN 1615-7591, E-ISSN 1615-7605, Vol. 25, no 3, p. 183-191Article in journal (Refereed) Published
Abstract [en]

A feed control strategy, based on estimated sugar concentrations, was developed with the purpose of avoiding severe inhibition of the yeast Saccharomyces cerevisiae during fermentation of spruce hydrolyzate. The sum of the fermentable hexose sugars, glucose and mannose, was estimated from on-line measurements of carbon dioxide evolution rate and biomass concentration by use of a simple stoichiometric model. The feed rate of the hydrolyzate was controlled to maintain constant sugar concentration during fed-batch fermentation, and the effect of different set-point concentrations was investigated using both untreated and detoxified hydrolyzates. The fed-batch cultivations were evaluated with respect to cellular physiology in terms of the specific ethanol productivities, ethanol yields, and viability of the yeast. The simple stoichiometric model used resulted in a good agreement between estimated sugar concentrations and off-line determinations of sugar concentrations. Furthermore, the control strategy used made it possible to maintain a constant sugar concentration without major oscillations in the feed rate or the sugar concentration. For untreated hydrolyzates the average ethanol productivity could be increased by more than 130% compared to batch fermentation. The average ethanol productivity was increased from 0.12 to 0.28 g/g h. The productivity also increased for detoxified hydrolyzates, where an increase of 16% was found (from 0.50 to 0.58 g/g h).

Place, publisher, year, edition, pages
2002. Vol. 25, no 3, p. 183-191
Keywords [en]
Dilute acid hydrolyzate, Ethanol, Fed-batch control, Inhibitors, Saccharomyces cerevisiae
National Category
Industrial Biotechnology
Identifiers
URN: urn:nbn:se:hb:diva-14833DOI: 10.1007/s00449-002-0293-xScopus ID: 2-s2.0-0036380161ISBN: 16157591 (ISSN) OAI: oai:DiVA.org:hb-14833DiVA, id: diva2:1236484
Available from: 2018-08-02 Created: 2018-08-02 Last updated: 2018-08-08Bibliographically approved

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Taherzadeh, Mohammad J

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