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Use of dynamic step response for control of fed-batch conversion of lignocellulosic hydrolyzates to ethanol
Department of Chemical Engineering II, Lund University of Technology.
Department of Chemical Engineering II, Lund University of Technology.ORCID iD: 0000-0003-4887-2433
Department of Chemical Engineering II, Lund University of Technology.
2001 (English)In: Journal of Biotechnology, ISSN 0168-1656, E-ISSN 1873-4863, Vol. 89, no 1, p. 41-53Article in journal (Refereed) Published
Abstract [en]

Optimization of fed-batch conversion of lignocellulosic hydrolyzates by the yeast Saccharomyces cerevisiae was studied. The feed rate was controlled using a step response strategy, in which the carbon dioxide evolution rate was used as input variable. The performance of the control strategy was examined using both an untreated and a detoxified dilute acid hydrolyzate, and the performance was compared to that obtained with a synthetic medium. In batch cultivation of the untreated hydrolyzate, only 23% of the hexose sugars were assimilated. However, by using the feed-back controlled fed-batch technique, it was possible to obtain complete conversion of the hexose sugars. Furthermore, the maximal specific ethanol productivity (qE, max) increased more than 10-fold, from 0.06 to 0.70 g g-1 h-1. In addition, the viability of the yeast cells decreased by more than 99% in batch cultivation, whereas a viability of more than 40% could be maintained during fed-batch cultivation. In contrast to untreated hydrolyzate, it was possible to convert the sugars in the detoxified hydrolyzate also in batch cultivation. However, a 50% higher specific ethanol productivity was obtained using fed-batch cultivation. During batch cultivation of both untreated and detoxified hydrolyzate a gradual decrease in specific ethanol productivity was observed. This decrease could largely be avoided in fed-batch cultivations.

Place, publisher, year, edition, pages
2001. Vol. 89, no 1, p. 41-53
Keywords [en]
Control, Dilute acid hydrolyzate, Ethanol, Fed-batch, Inhibitors, Saccharomyces cerevisiae
National Category
Industrial Biotechnology
Identifiers
URN: urn:nbn:se:hb:diva-14832DOI: 10.1016/S0168-1656(01)00283-8PubMedID: 11472798Scopus ID: 2-s2.0-0035954535ISBN: 01681656 (ISSN) OAI: oai:DiVA.org:hb-14832DiVA, id: diva2:1236481
Available from: 2018-08-02 Created: 2018-08-02 Last updated: 2018-08-08Bibliographically approved

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