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Gamma aminobutyric acid (GABA) production using acid lactic bacteria
University of Borås, Faculty of Textiles, Engineering and Business. Department of Biotechnology, University of Isfahan.ORCID iD: 0000-0003-4887-2433
Department of Biology, University of Isfahan.
Department of Biology, University of Isfahan.
2014 (English)In: Journal of Babol University of Medical Sciences, Vol. 16, no 8, p. 46-56Article in journal (Refereed) Published
Sustainable development
In my opinion, the content of this publication falls within the area of sustainable development.
Abstract [en]

BACKGROUND AND OBJECTIVE: Gamma-aminobutyric acid (GABA) is a non-protein amino acid that can be found broadly in all organisms. GABA is synthesized by glutamate decarboxylase (GAD). Therefore, GABA production depends on biochemical properties of this enzyme. GABA has several physiological functions such as hypotensive activity, insomnia, depression, as well as diuretic effects. Bacteria, fungi and yeast produce considerable amount of GABA. Among bacteria, acid lactic bacteria due to their physiological and safety properties have been considered. These bacteria are used in food industry and act as probiotics in digestive system. The aim of this study was to identify and introduce GABA producing acid lactic bacteria.

METHODS: In this paper using data banks such as PubMed and Google scholar and key words such as GABA producing acid lactic bacteria, isolation sources of them, factors that affect GABA production, acid lactic bacteria glutamate decarboxylase properties, glutamate decarboxylase gene cloning and regulation of them, the potential applications of GABA producing acid lactic bacteria and strain screenings have been reviewed.

FINDINGS: Data from variety of papers showed that production of GABA using acid lactic bacteria is safe and biocompatible. This may lead to GABA rich fermented products.

CONCLUSION: Results of this study showed that natural GABA has significant effects on human health. Therefore it seems acid lactic bacteria are the most suitable sources for GABA production. 

Place, publisher, year, edition, pages
Babol University of Medical Sciences , 2014. Vol. 16, no 8, p. 46-56
Keywords [en]
Acid lactic bacteria, Fermentation, Gamma-aminobutyric acid, Glutamate decarboxylase
National Category
Other Industrial Biotechnology
Identifiers
URN: urn:nbn:se:hb:diva-14848Scopus ID: 2-s2.0-84926363709ISBN: 15614107 (ISSN) OAI: oai:DiVA.org:hb-14848DiVA, id: diva2:1236339
Available from: 2018-08-01 Created: 2018-08-01 Last updated: 2018-08-08Bibliographically approved

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Taherzadeh, Mohammad J

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