Functionality, wearability, and user acceptance are critical issues for the development and eventual commercialization of the smart products. The use of smart clothing for medical reasons requires an understanding of the users’ perspective and the willingness to use the products. In this study, a smart clothing system has been developed for respiratory monitoring. Besides the functionality, the wearability from users' perspective has been considered though the design phases. Wearability and user acceptance have been examined by two questionnaires. Results shown the smart clothing system improves comfort and wearability compared with the ordinary respiratory monitoring device and most of the participants believe that using a smart clothing system will improve both health condition and quality of life.