Effects of antimicrobial compounds on dry anaerobic digestion (dry-AD) processes were investigated. Four compounds with known inhibition effects on traditional wet digestion, i.e. car-3-ene, hexanal, 1-octanol and phenol were selected and investigated at concentrations of 0.005%, 0.05% and 0.5%. Food waste (FW) and Paper waste (PW) were used as model substrates, all assays were running with the substrate to inoculum ratio of 1:1 (VS basis) corresponding to 15% TS in reactors. Generally, increasing concentrations of inhibitors resulted in decreasing methane yields with a few exceptions; in all these specific cases, long, lag phase periods (60 days) were observed. These adaptation periods made possible for the microbial systems to acclimatize to otherwise not preferred conditions leading to higher methane yields. Comparing the effects of the four different groups, phenols had the highest inhibitory effects, with no methane production at the highest amount added, while the lowest effects were obtained in cases of car-3-ene. Furthermore, the results showed that adding inhibitors up to a certain concentrations can repair the balance in AD process, slowing down the degradation steps, hence making it possible for the methanogens to produce a higher amount of methane. This phenomenon was not observed in case of PW, which is already a slow degradable substrate in its nature. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.