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Oxygen therapy in suspected acute myocardial infarction and concurrent normoxemic chronic obstructive pulmonary disease: a prespecified subgroup analysis from the DETO2X-AMI trial.
Unit of Cardiology, Karolinska Institutet,.
Uppsala Clinical Research Center, Uppsala University.
Uppsala Clinical Research Center, Uppsala University.
Department of Cardiology, Lund University.
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2019 (English)In: European heart journal. Acute cardiovascular care., ISSN 2048-8726, article id 2048872619848978Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (DETO2X-AMI) trial did not find any benefit of oxygen therapy compared to ambient air in normoxemic patients with suspected acute myocardial infarction. Patients with chronic obstructive pulmonary disease may both benefit and be harmed by supplemental oxygen. Thus we evaluated the effect of routine oxygen therapy compared to ambient air in normoxemic chronic obstructive pulmonary disease patients with suspected acute myocardial infarction.

METHODS AND RESULTS: =0.77]); there were no significant treatment-by-chronic obstructive pulmonary disease interactions.

CONCLUSIONS: Although chronic obstructive pulmonary disease patients had twice the mortality rate compared to non-chronic obstructive pulmonary disease patients, this prespecified subgroup analysis from the DETO2X-AMI trial on oxygen therapy versus ambient air in normoxemic chronic obstructive pulmonary disease patients with suspected acute myocardial infarction revealed no evidence for benefit of routine oxygen therapy consistent with the main trial's findings.

CLINICAL TRIALS REGISTRATION: NCT02290080.

Place, publisher, year, edition, pages
2019. article id 2048872619848978
Keywords [en]
Acute myocardial infarction, chronic obstructive pulmonary disease, oxygen, registry-based randomised clinical trial
National Category
Cardiac and Cardiovascular Systems
Research subject
Människan i vården
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URN: urn:nbn:se:hb:diva-22161DOI: 10.1177/2048872619848978PubMedID: 31081342OAI: oai:DiVA.org:hb-22161DiVA, id: diva2:1376438
Available from: 2019-12-09 Created: 2019-12-09 Last updated: 2019-12-27Bibliographically approved

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Herlitz, Johan

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