Introduction. This paper presents an exploration of how the notion of ”practice” is theorized and applied in library and information studies. Method. To highlight how “practice” is conceptualized and to discern what methodological approaches are taken, a qualitative analysis was conducted of a selection of practice-oriented contributions to the library and information studies literature. A bibliometric study of publications relating to “practice theory” provided a complementary quantitative overview of the influence of “the practice turn” in library and information studies. Analysis. Through reading a number of introductions to practice theories, a selection of prominent characteristics were identified. These characteristics provided guidance for the close-reading of the sample of practice-oriented library and information studies literature. As well as indicating direction for the qualitative analysis, the outcomes of the bibliometric study were recontexualized by the qualitative study. Results. The practice-oriented library and information studies literature can be divided into four different areas based on disciplinary influences. Authors are highlighting different key tenets when adhering to practice theory. It is possible to identify at least four different methodological approaches to empirical studies in the discipline.Conclusions. There is not one “practice-based approach” in library and information studies, but rather a multifaceted strand, which exhibits many different characteristics.