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Does indomethacin for closure of patent ductus arteriosus affect cerebral function?
Högskolan i Borås, Institutionen Ingenjörshögskolan.
Vise andre og tillknytning
2010 (engelsk)Inngår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 99, nr 10, s. 1493-1497Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: To study whether indomethacin used in conventional dose for closure of patent ductus arteriosus affects cerebral function measured by Electroencephalograms (EEG) evaluated by quantitative measures. Study design: Seven premature neonates with haemodynamically significant persistent ductus arteriosus were recruited. EEG were recorded before, during and after an intravenous infusion of 0.2 mg/kg indomethacin over 10 min. The EEG was analysed by two methods with different degrees of complexity for the amount of low-activity periods (LAP, “suppressions”) as an indicator of affection of cerebral function. Results: Neither of the two methods identified any change in the amount of LAPs in the EEG as compared to before the indomethacin infusion. Conclusion: Indomethacin in conventional dose for closure of patent ductus arteriosus does not affect cerebral function as evaluated by quantitative EEG.

sted, utgiver, år, opplag, sider
Wiley-Blackwell Publishing Ltd. , 2010. Vol. 99, nr 10, s. 1493-1497
Emneord [en]
Medicinteknik
HSV kategori
Identifikatorer
URN: urn:nbn:se:hb:diva-2846DOI: 10.1111/j.1651-2227.2010.01857.xLokal ID: 2320/6892OAI: oai:DiVA.org:hb-2846DiVA, id: diva2:870940
Tilgjengelig fra: 2015-11-13 Laget: 2015-11-13 Sist oppdatert: 2017-11-13bibliografisk kontrollert

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